I watched the original animated Æon Flux on MTV, but I have no idea how closely the film followed the original, because I don't believe I ever saw a single episode while sober.
Charlize Theron is too pretty to be Æon Flux. Julia Roberts is homely enough, but hardly the action star type. Angelina maybe? I'm wracking my brain to think of who could have been a better Æon Flux, but I'm coming up blank, so I guess Charlize was okay.